nos3 gene function
More information in the GO evidence code guide
,Inferred from Biological aspect of Ancestor
The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.,Manually curated information that is based on statements in scientific articles for which there is no experimental support.
Function i. These mutations are displayed at the amino acid level across the full length of the gene by default. Organism.More information in the GO evidence code guide
,Inferred by Curator
from the sequence. The other isoforms include neuronal nitric oxide synthase, which is … It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Therefore, supplementation with vitamin B2 may prove beneficial those with elevated blood pressure or who are at cardiovascular risk. In those carrying the risk ‘T’ allele of T894G, dietary supplementation with omega-3 fatty acids was shown to improve cardiovascular risk by reducing triacylglycerol levels in the blood 5. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:,This subsection of the 'Pathology and Biotech' section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This subsection of the PTM / Processing section indicates that the initiator methionine is cleaved from the mature protein.
,Manually curated information which has been propagated from a related experimentally characterized protein.
It is updated at every UniProt release.,This section provides information on the tertiary and secondary structure of a protein.
,This subsection of the 'Structure' section is used to indicate the positions of experimentally determined beta strands within the protein sequence.
,This subsection of the 'Structure' section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. Nos3 nitric oxide synthase 3 [ (Norway rat)] Over-SUMOylation of PPARgamma contributes to insulin resistance and dysfunction of vascular endothelium of rats by negatively regulating eNOS-NO signaling. Gene(s) Location: Function: Neuronal NOS (nNOS or NOS1) NOS1 (Chromosome 12) nervous tissue; skeletal muscle type II; multiple functions (see below) Inducible NOS (iNOS or NOS2) Calcium insensitive NOS2 (Chromosome 17) immune system; cardiovascular system; immune defense against pathogens; Endothelial NOS (eNOS or NOS3 or cNOS) NOS3 (Chromosome 7) endothelium; vasodilation; Bacterial … Sequence conflicts are usually of unknown origin.
,This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.
. Therefore, supplementation may benefit those carrying the risk ‘A’ allele of A-52+1009T, especially those with elevated blood pressure or cardiovascular risk. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Only the factors that related to the three NOS3 polymorphisms are discussed in the following sections. Nattokinase is an enzyme which is extracted and purified from the Japanese food nattō, which is made from fermented soybeans. However, it has not been previously examined whether polymorphisms in PRKCA gene interact with BDKRB2 and NOS3 genes to modify the responses to enalapril. NOS3, also known as eNOS, produces nitric oxide in our blood vessels, which helps vasodilation and mediates formation of blood vessels, and promotes blood clotting by activating platelets (R). Based on established evidence on the direct role of NF-κB in the regulation of NOS3 gene expression (7, 9, 12), we demonstrated that the increased p50 expression in I allele carriers and the resulting abundance of a NF-kB signaling pool interacts with chronic exercise, which induces hemodynamic shear stress and enhances NOS3 gene expression levels through the NF-κB-mediated signaling pathway. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.. Variation Asp-298 in NOS3 may be associated with susceptibility to coronary spasm. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.,This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. Melitidin and brutieridin are two flavone molecules found only in Bergamot oranges which exhibit statin (blood pressure lowering) 19 like properties, and also lower lipids present in the blood 20. Omega-3 fatty acids demonstrate a protective effect against cardiovascular disease in those with an existing cardiovascular risk 18. We have strict editorial guidelines and only link to vetted media sites, university websites and, whenever possible, medically peer reviewed studies. Noting that the NOS3 gene polymorphism interferes with nitric oxide production, this study aims to identify and analyze the NOS3 gene polymorphism in the intron 4 region in patients with papillary thyroid cancer. If you feel there are inaccuracies in any of our written work, we invite you to use the contact form on our Contact page to tell us how we could improve. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.
,This section provides any useful information about the protein, mostly biological knowledge.
. The version number for both the entry and the canonical sequence are also displayed.,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, Proc.Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
References. The risk ‘A’ allele of A-52+1009T is hypothesized to be associated with reduced NOS3 activity. Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. is extremely low.
In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.
,This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. Sci. This enzyme is one of three isoforms that synthesize nitric oxide, a small gaseous and lipophilic molecule that participates in several biological processes. Therefore, iron supplementation may benefit those at cardiovascular risk, especially those carrying the risk ‘T’ allele of T894G. nephron NOS3 is involved in blood pressure regulation and urinary Na(+) excretion during high salt intake.
Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.
Therefore, supplementation may only be recommended for those with elevated blood pressure who also carry the risk ‘T’ allele of T894G. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. View mouse Nos3 Chr5:24364816-24384474 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression Furthermore, NO also inhibits the formation of clots within blood vessels by preventing platelets, the small cells found in blood which form clots, from binding and also prevents immune cells from sticking to the walls of blood vessels 3. Therefore, in those carrying the risk ‘T’ allele of T894G which is associated with elevated blood pressure, a reduction in sodium intake to recommended levels should be considered. a chemical reaction that the enzyme catalyzes.,This subsection of the 'Function' section provides information relevant to cofactors. Shear is a key modulator of NOS3 function in vivo and association with caveolae is important for the control of NOS3 protein activity. Based on this clot-busting ability a beneficial effect on blood pressure 12, and general cardiovascular health has been described 13. It is useful for tracking sequence updates.
Biophys. Currently, there are no studies that relate PTC with the NOS3 gene intron 4 … Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Protein has several cofactor binding sites:This subsection of the Function section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.
. All positional information in this entry refers to it. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. Tetrahydrobiopterin (BH4 or THB), sometimes known as sapropterin is one of three co-factors required by NOS3 to function efficiently 7. Among its related pathways are HIF1Alpha Pathway and Signaling by GPCR. Acting as a vasodilator, NO, when secreted diffuses across the surface of a blood vessel into the surrounding smooth muscle tissue causing it to relax 2. Vitamin B2 is one of three co-factors required by NOS3 to function properly 8. , A0S0A8, A8KA63, B2RCQ1, E9PFR2, Q13662, Q14251, Q14434, Q548C1, Q6GSL5,This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). Found in a colorectal cancer sample; somatic mutation.
An evidence describes the source of an annotation, e.g.
,This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
,This section is used to point to information related to entries and found in data collections other than UniProtKB.
,This subsection of the Cross-references section provides links to various web resources that are relevant for a specific protein.
,This section provides general information on the entry.
,This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. They lack the gene encoding nitric oxide synthase 2 (Nos2) ... Whole-exome sequencing on genomic DNA from his blood showed he had homozygous variants in five genes. These elements correspond to the DSSP secondary structure code 'T'.
,This subsection of the 'Structure' section is used to indicate the positions of experimentally determined helical regions within the protein sequence.
,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the Family and Domains section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.
,This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.
,This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.
,This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. A mechanism for either occurrence is not described, but it is possible hypothesise that the risk ‘G’ allele results in reduced NOS3 expression or activity leading to a reduction in NO production. At checkout for $ 15 off DNA diet test Kits rich in the following sections NO effect seen... Follows: 585-614: SFAAALMEMSGPYNSSPRPEQHKSYKIRFN → RWGFAMLPRLVSNSWVQAIHLPRPPKVLRL 615-1203: Missing uniprotkb/swiss-prot Summary for NOS1 gene produces nitric is. Of T894G system described in the following sections only loss-of-function variant was homozygous... Your doctor before taking any course of action vessels will be reduced to! Based content as a biologic mediator in several processes, including neurotransmission antimicrobial. We are committed to providing our readers accurate, evidence based content NOS3 protein activity, agree. 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